When twin brothers Bill and Hal find their father's old monkey toy in the attic, a series of gruesome deaths start. The siblings decide to throw the toy away and move on with their lives, growing apart over the years.

A priest named Father Burke is sent to Rome to investigate the mysterious death of a nun.

Several years after the tragic death of their little girl, a dollmaker and his wife welcome a nun and several girls from a shuttered orphanage into their home, soon becoming the target of the dollmaker's possessed creation, Annabelle.