Varisu is the story of a happy-go-lucky man, played by Thalapathy Vijay. Things change when his foster father dies unexpectedly, and he's in the middle of a multi-billion dollar empire.

Venky and Varun, who try to come up from financial problems. But what will happen when they meet Pragathi Family who are greedy for money.

Decades post-high school, Ram and Jaanu meet at their school's reunion and explore their past thoughts consisting of affection, care, depth and grieve all over the period of one evening.