A house is cursed by a vengeful ghost that curses those who enter it with a violent death.

A man kisses his wife and baby goodbye and seemingly heads away on business, with a plan to check into a hotel, call an escort service, and kill an unsuspecting prostitute.

In their secluded farmhouse, a mother, formerly a surgeon in Portugal, teaches her daughter, Francisca, to understand anatomy and be unfazed by death. One afternoon, a mysterious visitor shatters the idyll of Francisca's family...